Laboratory of skeletal biomedicine
Our lab uses a precision medicine approach to uncover mechanisms of disease and develop cell and gene therapies for skeletal disorders. To reach that goal we use a multidisciplinary approach that includes CRISPR gene edition, virus particle delivery, tissue engineering, biomaterials, advanced cytometry, genetics, stem cell biology, pharmacology and nanoimaging.
Our group has classically studied skeletal dysplasias, discovering and number of new genes, mechanisms and disorders that affect the skeleton.
Our group has classically studied skeletal dysplasias, discovering and number of new genes, mechanisms and disorders that affect the skeleton.
Our main goal is to develop new advanced therapies against bone fragility (Osteogenesis Imperfecta and Osteoporosis), short stature syndromes (achondroplasia) and other super-rare skeletal dysplasias. Our approach unravel new mechanisms of disease that connect cellular stress, metabolic alterations, inflammation and aging expanding in search of new and personalized therapies.
news
Using Precision Medicine to Uncover and Treat New Skeletal Disorders
Alteration of focal points revealing cell signaling problems in patients with skeletal dysplasia caused by mutations in LAMA5. Green represents immunofluorescence localization of Vinculin (focal adhesions), purple is Phalloidin (actin cytoskeleton) and blue represents nuclei.
El científico Iván Durán, premiado por un trabajo sobre un nuevo síndrome genético del esqueleto
El investigador del Departamento de Biología Celular de la UMA Iván Durán, también perteneciente al Instituto de Investigación Biomédica de Málaga (IBIMA) y al CIBER-BBN, ha recibido en el marco de la segunda reunión Interna del Área Transversal IBIMA- RARE…
Investigan en la UMA un nuevo fármaco que podría mitigar las consecuencias del Covid
Científicos del área de Biología Celular de la Universidad de Málaga y Bionand estudiará durante el próximo año cómo el tratamiento con 4-Fenilbutirato (4-PBA) modula la respuesta inflamatoria que se produce en los casos más graves de coronavirus.
Hacia una salud azul: los peces muestran enfermedades congénitas similares a las humanas
Manuel Marí Beffa e Iván J. Durán Jiménez, profesores de la UMA pertenecientes al grupo BIO217 sobre Biología y Fisiología Celular, han publicado recientemente una revisión bibliográfica sobre enfermedades congénitas de peces…
research projects
Skeletal Dysplasias
Our research follows the premises of precision medicine to uncover mechanisms of disease and develop advanced and personalized therapies.
Bone Fragility
Affects more than 200 million people in the world and includes diseases like osteoporosis and osteogenesis imperfecta, among others.
Inflammation
This project started before the COVID19 pandemics out of our interest in inflammatory response in respiratory diseases.
Skeletal metabolism
Skeletal stem cells (SSCs) have the ability to differentiate into bone, cartilage and fat; the balance between bone and fat is disrupted in various human diseases.
Precision Therapies
One of our main goals is to find next-generation therapies, which will allow us to generate more precise treatments for almost any human condition.
Biomaterials
Bone 3D-in vitro culture was among the first and most successful approaches in bioengineering.
Tissue Engineering
This project is a basic research extension of our core project focused in precision medicine of skeletal diseases.
RNA-seq unicelular
Transcriptomic results from public and in-house laboratories from single cells and single RNA-seq are a vast source of information.
Networking
